Frequent question: Which statement about somatic mutations is true?

What is true somatic mutation?

An alteration in DNA that occurs after conception. Somatic mutations can occur in any of the cells of the body except the germ cells (sperm and egg) and therefore are not passed on to children. These alterations can (but do not always) cause cancer or other diseases.

Is true about mutations in somatic cells?

Somatic cells give rise to all non-germline tissues. Mutations in somatic cells are called somatic mutations. Because they do not occur in cells that give rise to gametes, the mutation is not passed along to the next generation by sexual means.

What are somatic mutations responsible for?

There is a general lack of knowledge on the exact mechanism of somatic mutations outside of the setting of carcinogenesis.[2] However, somatic mutations are also responsible for general cell aging and disease occurring later in life. Most mutations within somatic tissues are random and rarely beneficial to organisms.

Which disease is the result of somatic mutation?

Somatic mutations can give rise to cancer (9), as well as noncancerous diseases. Noncancerous somatic mutations that occur during development may affect cell proliferation, as would be the case in cancer, or they may simply alter cellular function without causing a proliferative effect.

Can somatic mutations be repaired?

Somatic mutations are permanent unless altered by genome editing. If a particular treatment eliminates/kills off all cells harboring the particular mutation that lead to the malignant phenotype then you’re not really fixing the mutation. it is possible to revert a mutation, but the process is really rare.

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How do you test for somatic mutations?

Somatic variants are detected by either testing the tumor directly or liquid biopsy of a blood sample with circulating tumor cells to identify the DNA sequencing changes driving tumor growth. Understand the variants for a particular malignancy may help providers determine which therapies might be most effective.

Why are somatic mutations temporary?

Somatic mutations are abundant in most cells of our tissues. The impact of any somatic mutation may be small and temporary if it occurs in differentiated cells without giving rise to malignant growth by unlocking their terminal differentiation.